As a late clinical-stage biopharmaceutical company focused on oncology, our business model is to in-license novel compounds, develop them through clinical stages, and then partner with pharmaceutical companies for further clinical development and/or commercialization.

Our lead program, motixafortide (BL-8040), is a cancer therapy platform that was evaluated in a Phase 3 study in stem cell mobilization for autologous bone-marrow transplantation. Our outstanding phase 3 results support goal of Motixafortide becoming standard-of-care mobilization agent for autologous bone-marrow transplantation.

Motixafortide was also successfully evaluated in a Phase 2a study for the treatment of pancreatic cancer in combination with KEYTRUDA® and chemotherapy under a collaboration agreement with MSD. Substantial improvement was observed across all study endpoints, including overall survival, progression free survival, and overall response rate, in the most challenging PDAC patients. The asset was also successfully evaluated in a Phase 2 study in r/r AML.

Motixafortide is currently being studied in two notable investigator-initiated trials: in a Phase 2 study for the treatment of pancreatic cancer in combination with LIBTAYO® and chemotherapy and in a Phase 1b study for patients with Acute Respiratory Distress Syndrome (ARDS) Secondary to COVID-19 and Other Respiratory Viral Infections.

We are also developing a second oncology program, AGI-134, an immunotherapy treatment for multiple solid tumors, that is currently being investigated in a Phase 1/2a study.

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